Digestive Health & Nausea > Motilium (Generic)

Motilium (Generic)
Motilium (Generic) logo

Main information about Domperidone

Domperidone, known under the brand name Motilium to name a few, is a peripherally elective dopamine D2 receptor antagonist that was produced by Janssen Pharmaceutica and also is made use of as an antiemetic, gastroprokinetic agent, as well as galactagogue. Generic Motilium (Domperidone) (Motilium (Domperidone)) is an antidopaminergic medication that is utilized to surpress the sensations of nausea or vomiting and also retching. Motilium is made use of to supress queasiness as well as vomiting, and functions mainly by blocking dopamine receptors located in the upper end of the gastrointestinal system. This triggers firm of the muscular tissues at the entry to the stomach, leisure of the muscles at the end point of the tummy as well as boosted contraction of the muscles in the tummy itself. These actions accelerate the flow of food via the belly into the intestine, which physically assists stop retching as well as reduces feelings of sickness, bloating and also bellyful. You need to take Common Motilium (Domperidone) pills with a cup of water 15 to Thirty Minutes before meals. If you more than 16, you could take a tablet 3 times every day and at bedtime. To raise breastmilk the dosage suggested by lactation consultants is up to 2 pills 4 times every day. Adverse effects include: allergic reactions, like rash or urticaria; stomach cramps; dystonic reactions (extrapyramidal phenomena). Reversible raised product prolactin levels have actually been observed which could cause galactorrhoea and gynaecomastia.

Domperidone Purchase

Everybody can painlessly purchase Domperidone online with a help of our website. Nevertheless you should take your health with a great care. Before you make up your mind to order Motilium, you should discuss this with a doctor. Any self-medication combined with improper medication can hurt you severely.

Product Options

Quantity Our Price Price Per pill You save
30 pills
60 pills
90 pills
120 pills
180 pills

Product Info

Uses

Generic Motilium is used to supress nausea and vomiting, and works primarily by blocking dopamine receptors found in the upper end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach and so prevents reflux (regurgitation of the stomach contents back into the foodpipe).

How to take

You should take Generic Motilium tablets with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime. To increase breastmilk the dosage recommended by lactation consultants is up to TWO tablets FOUR times a day.

Side effects

Side effects include:

  • Allergic reactions, such as rash or urticaria.
  • Abdominal cramps.
  • Dystonic reactions (extrapyramidal phenomena) may occur.
  • Reversible raised serum prolactin levels have been observed which may lead to galactorrhoea and gynaecomastia.
  • Hypertensive crises in patient.

 

Precautions

Since domperidone is highly metabolised in the liver, domperidone should be used with caution in patients with hepatic impairment (and in the elderly).

Domperidone should be used with caution in patients with renal impairment or in those at risk of fluid retention. In patients with severe renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, depending on the severity of impairment, and the dose may need to be reduced. Patients on prolonged therapy should be reviewed regularly.

Drug interactions

Antacids and anti-secretory agents lower the oral bioavailability of domperidone. They should be taken after meals and not before meals, i.e. they should not be taken simultaneously with domperidone.

Reduced gastric acidity impairs the absorption of domperidone.

Oral bioavailability is decreased by prior administration of cimetidine or sodium bicarbonate.

The main metabolic pathway of domperidone is through CYP3A4. In vitro data suggests that concomitant use of drugs that significantly inhibit this enzyme may result in increased plasma levels of domperidone.

Examples of CYP3A4 inhibitors include the following:

  • azole antifungals
  • macrolide antibiotics
  • HIV protease inhibitors
  • nefazodone

Missed dose

If you miss a dose of Generic Motilium, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

Storage

Store below 25 degrees Celsius, away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.