Inform your doctor of your entire medical history, including: diabetes, asthma, epilepsy, high blood pressure, migraines, liver or kidney disease, heart strokes, depression, toxemia, jaundice during pregnancy, excessive fluid retention and weight gain during menstruation, uterine fibroid tumor, abnormal vaginal bleeding, gallbladder disease, cholesterol, lipid problems or blood clots. Provide information on your family medical history too, especially of breast cancer and lumps.
If you are going to have a surgery, inform your medical specialist about taking this medication. Premarin, especially in high doses, can cause melisma (darkening of the color of skin and face). In order to not increase this effect, avoid exposure to sunlight. Consult your doctor about the use of protecting clothing and sunscreens. Patients (especially women past 35) should avoid smoking while taking the medication as it may increase the risk of blood clots.
Pregnant women must not use the medication. If you are pregnant or suspect pregnancy, consult your doctor immediately. Breast-feeding women are not advised to use the medication as it may pass into breast milk.