Anticonvulsants > Sinemet (Generic)

Sinemet (Generic)
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Sinemet Summary

Sinemet (Carbidopa/levodopa), additionally referred to as levocarb and co-careldopa, is the combination of both medicines carbidopa and levodopa. This mix drug is made use of to cure signs and symptoms of Parkinson's illness or Parkinson-like signs and symptoms (such as shakiness, tightness, problem moving). Parkinson's disease is assumed to be triggered by also little of a normally taking place substance (dopamine) in the brain. Levodopa become dopamine in the brain, helping to control activity. Carbidopa stops the failure of levodopa in the bloodstream so a lot more levodopa could enter the brain. Carbidopa can additionally reduce a few of levodopa's side effects like queasiness and also vomiting. If you currently take levodopa, you should stop taking it a minimum of 12 hrs before you start taking Sinemet. Sinemet could be taken regardless of taking food. Take your dosages at regular intervals to maintain a constant quantity of the drug in your body at all times. Get your prescription refilled prior to you run out of medication totally.Never crush, chew, damage, or open a Sinemet capsule. Ingest it entire. You might see that your sweat, urine, or saliva appears dark in color, such as red, brownish, or black. This is not a hazardous adverse effects, yet it could cause discoloration of your clothes or bed sheets. Get emergency medical assistance in case you experience any of these indications of an allergic response: hives; problem breathing; swelling of your lips, face, tongue, or throat. You must inform your medical professional urgently in case you have any one of these severe adverse effects: uneasy muscle movements in your eyes, tongue, jaw, or neck; aggravating of shakes.

Ordering Sinemet online

Everybody can quickly order Sinemet on the internet by using our site. Nevertheless you must take your health with a great care. Even if you have already read the direction cautiously and you are sure this medication will eventially comfort you, constantly keep in mind to consult your doctor first.

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Generic Sinemet is used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control. This medication is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication.

The active ingredient in Generic Sinemet, Levodopa is converted to dopamine via the action of a naturally occurring enzyme called DOPA decarboxylase. This occurs both in the peripheral circulation and in the central nervous system after levodopa has crossed the blood brain barrier. Activation of central dopamine receptors improves the symptoms of Parkinson's disease.

How to take

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Generic Sinemet can be taken with or without food. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The regular tablet can be broken or crushed if needed to make it easier to swallow.

To take the orally disintegrating tablet:

  • Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.
  • Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.
  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves.

Side effects

You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • worsening of tremors (uncontrolled shaking);
  • high fever, stiff muscles, sweating, fast or uneven heartbeats, rapid breathing, feeling like you might pass out;
  • seizure (convulsions);
  • painful or difficult urination;
  • severe nausea, vomiting, or diarrhea;
  • uneven heart rate or fluttering in your chest;
  • confusion, hallucinations, anxiety, agitation, depressed mood, thoughts of suicide or hurting yourself;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder.

Less serious side effects may include:

  • mild nausea, dry mouth, loss of appetite, heartburn, diarrhea, constipation;
  • headache, dizziness, drowsiness, blurred vision;
  • sneezing, stuffy nose, cough, or other cold symptoms;
  • sleep problems (insomnia), strange dreams;
  • muscle pain, numbness or tingly feeling; or
  • skin rash or itching.

This is not a complete list of side effects and others may occur.


Do not take Generic Sinemet if:

  • you have an allergy to Generic Sinemet
  • you have any unusual skin lumps or moles which have not been examined by your doctor,
  • or if you have ever had skin cancer or melanoma
  • you have a type of glaucoma called narrow-angle glaucoma

Avoid taking iron supplements or eating a diet that is high in protein (protein sources include meat, eggs, and cheese). These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication.

If you are unsure of how this medicine will affect you, be careful if you drive or do anything that requires you to be awake and alert.

Drug interactions

Tell your doctor about all other medicines you use, especially:

  • other Parkinson's medications;
  • Generic Maxolon (Reglan);
  • isoniazid (Nydrazid);
  • phenytoin (Dilantin);
  • papaverine (Pavabid, Papacon, Pavagen, Pavacot);
  • blood pressure medication;
  • an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), Generic Nortriptyline (Pamelor), and others; or
  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), prochlorperazine (Compazine), risperidone (Risperdal), and others;

This list is not complete and other drugs may interact with Generic Sinemet.

Missed dose

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


Store at room temperature away from moisture, heat, and light.